Over the next half century, although other supportive nutrients have been discovered, orthomolecular physicians and researchers have continued to find megadose vitamin B3 and megadose vitamin C to be major therapeutic agents for most adult psychoses. This applies to all biotypes, even histadelia (more on biotypes later).
That is, niacin and C, within the context of a complex of indicated nutrients, health therapies, and other treatments, as per individual biochemical requirements, including contraindications.
For references, consult the literature, and see Natural Healing for Schizophrenia
* Some exceptions: for pyrolurics and for young people, B6 or B6 plus B3, may often be more effective than B3 alone.